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PathcoreFlow Release Notes

PathcoreFlow™ Release Notes

v4.3 (2026-01-28)

This release of PathcoreFlow features improved compatibility with third-party systems, enhanced security, improvements to the user experience and reliability, and bug fixes.

New Features

Hamamatsu MoxiePlex Support

PathcoreFlow has added support for Hamamatsu's MoxiePlex image format (an OME-TIFF variant).

Improvements

Login Flow

The login page for PathcoreFlow has the same look and feel, however the underlying functionality and workflow has been completely overhauled for better compatibility with browser-integrated password managers and SSO providers.

This improvement should also alleviate problems some users had with logging in and out.

Visiopharm Integration

Added a number of improvements to the Visiopharm (VIS) integration to better support complex (multi-step) analysis spanning multiple Open-in-VIS / Export-to-PathcoreFlow cycles. These improvements include the ability to select the MLD sent to VIS from PathcoreFlow when launching VIS and automatically resolving overlapping VIS ROIs and PathcoreFlow annotations.

  • New MLD files are created when sending PathcoreFlow annotations to VIS, rather than modifying the MLD file received from VIS, in order to prevent the ROI stacking effect
  • PathcoreFlow annotations that overlap with existing VIS ROIs are now clipped before being sent to Visiopharm. Previously, only overlaps between PathcoreFlow annotations were clipped
  • An option has been added to the "Open in VIS" dialog which allows the user to choose the MLD file that is sent to VIS on launch or none at all

Image Format Upgrades

Added support for Evident (formerly Olympus) VSI images with Max Intensity Projection (MIP) stacks. Previously affected sub-images are now visible in the Viewer.

Expanded the range of supported wavelengths for NDPIS images to include emission wavelengths outside of 380 to 780 nm. Previously, these wavelengths rendered as black.

Added support for embedded ICC profiles in Hamamatsu NDPI images which can improve rendering fidelity for images that have them.

Other Improvements

  • "Figures" has been added to the list of item types that can be searched on the Search page

Fixed in this Release

Image Format Fixes

  • Corrected a problem with certain OME-TIFF images where the magnification could not be read from the image metadata

Security Fixes

  • Fixed a potential XML parsing vulnerability related to image metadata and Visiopharm integration
  • Many other security improvements and upgrades

Viewer Fixes

  • Fixed an issue where histograms for certain CZI images would not be generated
  • Fixed an issue where the Viewer could become unresponsive when applying default image settings
  • Corrected a problem with certain Hamamatsu MoxiePlex images where the macro image would not be recognized as such, causing it to be displayed in the Viewer alongside the main image
  • Fixed a problem with the "Add image overlay" dialog that would use an incorrect URL to link to the image to which the overlay was added
  • Fixed a problem that caused a "Something went wrong" error when viewing a fluorescence image if it had bands with empty names

Repository Fixes

  • Fixed an issue that prevented label images from appearing in folder listings even when enabled
  • Corrected a problem where navigating to an invalid folder ID could produce excessive network traffic
  • Fixed issues with the folder quick search showing fewer or no results when the search included a special character
  • Fixed a problem where certain options were displayed to users of share links, even though the actions would fail due to insufficient permissions. These include:
    • Rotating the image label
    • Editing the image description
    • Marking an image as read or favorite
    • Clearing the heat map
    • Deleting a Visiopharm result
    • Deleting or renaming a snapshot
  • Fixed an issue that could cause the "Region Download Link" column in the "View Tracking" report to have the wrong URL when collecting annotations via a share link

Indexing Fixes

  • Fixed a problem with the indexing service taking longer than expected to detect changes to an existing file resulting from an inefficient database query
  • Added scaling to the index service check in interval time so modification checks are made more often for newer files than older files